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*More advanced age, risk for toxicity, renal impairment, or patient preference; ˆIn case of contraindication for ibrutinib, with Pneumocystic jiroveci pneumonia prophylaxis and cytomegalovirus monitoring; ˆˆIn case of contraindication for both ibrutinib and idelalisib; ∼Take into account decreased toxicity with R versus increased progression-free survival with obi. Figure 1 First-line Treatment Abbreviations: B = bendamustine; C = cyclophosphamide; Cb = chlorambucil; CLL = chronic lymphocytic leukemia; F = fludarabine; Obi = obinutuzumab; Ofa = ofatumumab; R = rituximab.

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